Evaluation of Tissumend II Sterile as a Multipurpose Absorbable Tissue Adhesive

Radiochemically sterilized Tissumend II Sterile was evaluated as an absorbable tissue adhesive/sealant for: 1) repairing corneal defects in rabbit models; 2) augmenting kidney incisional wounds in rabbits; and 3) sealing lacerated lung tissue in cats and dogs. Immediate post-surgical evaluation of treated sites indicated timely curing of tissue adhesives. Retrieved tissues from application sites were evaluated for histological changes 1 to 3 weeks following surgical procedures. Available data indicate a moderate tissue response at 1 week that subsided at 2 and 3 weeks. All surgical sites were almost completely healed at 3 weeks. All animals survived, reflecting excellent functional performance of adhesive. INTRODUCTION The use of tissue adhesives as alternative or adjunct means to sutures and staples in tissue repair has been suggested by surgeons for a number of decades. In fact, tissue